Analysis of Factors Related to the Efficacy of Consciousness-Regaining Therapy for Prolonged Disorder of Consciousness: A Retrospective Cohort Study

Abstract

To analyse the factors related to the efficacy of consciousness-regaining therapy for prolonged disorder of consciousness. A retrospective analysis was conducted on the case data of 114 patients with pDOC admitted to the Department of Functional Neurosurgery of Tianjin Huanhu Hospital from January 2019 to January 2022 to explore the relevant factors that affect the efficacy of consciousness-regaining therapy (CRT) for prolonged disorder of consciousness (pDOC). Next, basic information on the cases, data on pDOC disease assessment, CRT methods, and efficacy evaluation were collected. These 114 patients were grouped, and a comparative analysis was done based on the efficacy at the end of treatment. Of these, 61 cases were allotted to the ineffective group and 53 cases to the effective group. There was a lack of statistical difference (P > 0.05) between the two groups based on gender, age, etiology, acute cerebral herniation, emergency craniotomy surgery, emergency decompressive craniectomy, time from onset to start of CRT, and CRT duration (P > 0.05). However, secondary hydrocephalus, CRT methods, CRS-R grading before treatment, and GOSE score at six months after treatment were found to be statistically different. The results of binary logistic regression analysis showed that the type of therapy (OR = 0.169, 95% CI: 0.057-0.508) affected the efficacy of CRT (P < 0.05). Personalized awakening therapy using various invasive CRT methods could improve the efficacy of therapy for pDOC compared with non-invasive therapy.