Analysis of NSE, S100B and hemodynamic changes in microsurgical treatment of prognosis and outcome in patients with intracranial aneurysms

Abstract

Objective To investigate the changes of neuron-specific enolase (NSE) and S100B protein and hemodynamic changes in the prognosis and outcome of patients with intracranial aneurysms treated by microsurgery. Methods Sixty elderly patients with intracranial aneurysms undergoing microsurgery treated in the Department of Neurosurgery, Danyang People’s Hospital from January 2014 to January 2017 were selected as the observation group. Sixty elderly healthy subjects were selected as the control group. Fasting venous blood was collected in the early morning before and on the day of discharge, and the changes of NSE and S100B levels and hemodynamic parameters were measured before and after surgery. Patients in the observation group were followed up, and the prognosis and outcome of the patients were evaluated by the GOS. Results Compared with the control group, the expression of serum NSE and S100B protein in patients with intracranial aneurysms increased significantly, the intracranial pressure (ICP) increased significantly, and the cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) decreased significantly; after microsurgery treatment, the serum NSE and S100B expression decreased significantly, the patient’s ICP decreased significantly, CBF, CBV and MTT increased significantly (P<0.05). After the 6-month follow-up, the prognosis was assessed by GOS score, with 10 deaths, 16 poor prognosis, and 34 good prognosis. As the patient’s GOS score decreased, the patient’s NSE and S100B expression levels increased significantly, and the difference was of statistical significance (P<0.05). There was a positive linear correlation between expression levels of serum NSE and S100B, and the lower the GOS score, the higher the expression levels of NSE and S100B (P<0.05). As the patient’s GOS score decreased, the patient’s ICP increased significantly, CBF, CBV, and MTT decreased significantly, and the difference was of statistical significance (P<0.05). There was a positive linear correlation between prognosis and ICP, CBF, CBV, MTT (P<0.05). Conclusion S100B, NSE and hemodynamic changes are significantly associated with microsurgical treatment for prognosis and outcome in patients with intracranial aneurysms. Testing S100B, NSE, and hemodynamic changes have important diagnostic auxiliary implications for clinical outcomes and prognosis in patients. Key words: Neuron-specific enolase; S100B; Hemodynamics; Microsurgery; Intracranial aneurysm