Abstract
Melanoma is malignant disease and the incidence of melanoma has been increasing worldwide, resulting in an important socio-economic problem especially in not well development countries. At the time when the incidence of many tumors is decreasing, melanoma incidence continues to increase. Incidence in Southern Europe is ranging from 1,9/100.00 in Albania across 3,3/100.000 in Bulgaria to 14,5/100.000 in Slovenia and in Serbia 8,5/100.000 for male and 5,9/100.000for female (ASR-W, 2012). In Serbia, during 2007 to 2012, according to Cancer Registry of Central Serbia, there are about 622 new melanoma diagnoses, 320 male and 302 female. During 2012, in Republic of Serbia melanoma was the 10th most common diagnosed cancer and 12th most common cancer caused death, in both, females and males. The aim of this study was to analyzed clinical and epidemiological characteristic of melanoma. Retrospective study, data analysis, all patients referred and treated in two year period in Clinic for Burns, plastic and reconstructive surgery, Clinical Center of Serbia, Belgrade. All data are collected in hospital based registry The analyzed characteristics of interest: sex, age, subtype of melanoma, primary location of melanoma, Breslow thickness and Clark level of invasion, number of mitosis, ulceration, TNM stadium, the presents of microsatellites, metastases, level of Protein S and LDH and decision of future treatment . Decision about future treatment are made according AJCC (re-excision and SLNB – Sentinel Lymph Node Biopsy ) and follow-up of patients after SLNB is still lasting. In two year period, 201 patients were treated in our hospital, all patients in this study were with pathohistologically verified diagnoses of melanoma. The average age of patients was 61, 47 ( 25 - 87). The most common primary location of melanoma was trunk with some differences between sexes. The most common subtype of melanoma was superficial subtype in 69% of patients. Ulceration were present in 22% of all primary melanomas and mitosis in 47, 5% and microsatellites in 3, 5%. Protein S and LDH level were elevated in patients with higher Breslow thickness. According to the AJCC protocol we made a decision about future treatment, re-excision and SLNB. The follow-up after SLNB is still lasting and we are still collecting data. The study showed the correlation between subtype of melanoma, higher Breslow thickness and the level of invasion by Clark, as well as elevated level of protein S and LDH and the presents of ulcerations and mitosis with decision about future treatment according to AJCC protocol.
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