Analysis of effect of salmeterol, fluticasone propionate combined with tiotropium bromide in the treatment of elderly patients with chronic obstructive pulmonary disease

Abstract

Objective To evaluate the clinical curative effect of salmeterol, fluticasone propionate combined with tiotropium bromide in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD), thus to provide reference for the clinical treatment. Methods 76 patients with moderate and severe COPD were randomly divided into observation group and control group, 38 cases in each group.The control group on the basis of COPD conventional treatment, received salmeterol, fluticasone propionate inhalation therapy.The observation group was treated with the treatment of the control group and treated with the inhalation of tiotropium bromide.The lung function tests, C reactive protein and T lymphocyte subsets were compared between the two groups before and after treatment. Results After treatment, FEV1, FEV1/FVC, FEV1% in the two groups were significantly higher than before treatment (t=4.25, 4.43, 3.98, 4.12, 4.26, 4.07, all P<0.05).After treatment, FEV1, FEV1/FVC, expected value for FEV1% in the observation group were (2.45±0.35)L/s, (63.91±7.42)%, (47.29±7.52), which were significantly higher than those of control group (t=3.68, 4.03, 4.18, all P<0.05).After treatment, C reactive protein, CD8+ in the two groups were significantly lower than those before treatment, while CD4+, CD4+/CD8+ were significantly higher than those before treatment (t=4.45, 3.99, 5.13, 3.86, 4.13, 4.59, 3.89, 4.03, all P<0.05).After treatment, C-reactive protein, CD+ 8 of the observation group were (10.38±3.12)mg/L, (22.47±2.13)%, which were significantly lower than the control group, and CD4+ (31.62±4.22)%, CD4+/CD8+ (1.43±0.20) were significantly higher than control group (t=4.46, 4.17, 3.92, 4.72, all P<0.05). Conclusion Salmeterol, fluticasone propionate combined with tiotropium bromide in the treatment of elderly patients with COPD can significantly improve the patients' lung function, reduce the inflammation reaction, improve the patients' immune function, alleviate the patients' disease. Key words: Pulmonary disease, chronic obstructive; Salmeterol; Fluticasone propionate; Tiotropium bromide; Aged