Analysis of drug resistance of Mycobacterium tuberculosis in Jincheng

Abstract

Objective To study the situation of drug-resistance of Mycobacterium tuberculosis in Jincheng, in order to select more effective, scientific and reasonable anti tuberculosis drugs, and to provide evidence for the prevention and control of drug-resistant tuberculosis. Methods Drug sensitivity tests were carried out by sputum culture and the proportional method in all patients. They were active pulmonary tuberculosis and sputum smear-positive from October 2015 to October 2016 in Jincheng. Statistical analysis was performed with χ2-test. Results A total of 162 strains of Mycobacterium tuberculosis (MTB) were isolated. The total drug-resistance rate was 20.99%(34 strains), which was lower than the fifth epidemic result in 2010 for China(36.8%). The rates of single drug resistance(SDR), poly-drug resistance(PDR) and multi drug resistance (MDR) were 4.3%(7/162), 4.94%(8/162) and 11.11% (18/162). MDR was much higher than the fifth epidemic result in 2010 for China(36.8%), but they were almost the same as the level in one hospital of Taiyuan from 2011 to 2013. The initial drug-resistance was 16.15%(21/130), while the acquired resistance rate was 40.63%(13/32), there was significant difference between them(χ2=9.273, P 0.05). Conclusions The total drug resistance rate is lower than the epidemic level in 2010 for China, but MDR is higher. It is very important in drug resistance tuberculosis prevention and control in Jincheng. Key words: Tuberculosis; Mycobacterium tuberculosis; Drug sensitivity test; Drug resistance