Abstract
Objective To analyze the distribution of human papilloma virus (HPV) infection in women with cervical lesions of different grades and analyze the relationship of high-risk HPV and cervical lesions in order to facilitate targeted prevention. Methods The infection status of HPV subtype was statistically analyzed in patients who underwent colposcopy examination from April 2017 to June 2019. Results The infection rate of HPV was 81.4% in chronic cervicitis, 82.9% in 1ow-grade squamous intraepithelial lesion (LSIL), 63.7% in HSIL (high-grade squamous intraepithelial lesion), and 50% in cervical squamous cell carcinoma (CSCC). Among the 16 high-risk HPV types, the top six HPV types with the comprehensive infection rates were HPV16 > HPV52 > HPV58 > HPV18 > HPV51 > HPV53 in turn, and the infection rates were 23.3%, 14.8%, 13.3%, 9.8%, 9.2%, and 8.8%, respectively. The infection rates of HPV16 in chronic cervicitis group, LSIL group, and HSIL group were significantly different. There was no significant difference in the injection rates of HPV52, HPV58, and HPV18 among the three groups. HPV infection rates were highest in the 31–40 years old group, followed by the 41–50 years old group. Conclusion The distribution of different types of HPV varies in different tissue types, which can be used to develop relevant vaccines to achieve better prevention and treatment of cervical cancer.
Highlights
Cervical cancer, one of the most common gynecological malignancies, is the fourth most common cancer among women
Human papilloma virus (HPV) infection is a high-risk factor leading to cervical cancer, which seriously affects women’s physical and mental health and reproductive outcomes [3]. e occurrence of cervical squamous intraepithelial lesion (SIL) and cervical cancer is mainly related to the persistent high-risk HPV infection
HPV16 and 18 infections account for 70% of cervical cancer, while the other 12 high-risk HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, and 73) account for 1–9% of cervical cancer [4]. is article analyzed the distribution of different types of HPV in different tissue types of cervical lesions, which played an important role in the prevention, diagnosis, and treatment of cervical cancer
Summary
One of the most common gynecological malignancies, is the fourth most common cancer among women. E number of new cases of cervical cancer in China is increasing at a rate of 15,000 per year, ranking the second in the world [2]. Human papilloma virus (HPV) infection is a high-risk factor leading to cervical cancer, which seriously affects women’s physical and mental health and reproductive outcomes [3]. E occurrence of cervical squamous intraepithelial lesion (SIL) and cervical cancer is mainly related to the persistent high-risk HPV infection. More than 30 types of HPV are known to be associated with reproductive tract infections. High-risk HPV is the type associated with genital cancers, especially cervical cancer. HPV16 and 18 infections account for 70% of cervical cancer, while the other 12 high-risk HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, and 73) account for 1–9% of cervical cancer [4]. HPV16 and 18 infections account for 70% of cervical cancer, while the other 12 high-risk HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, and 73) account for 1–9% of cervical cancer [4]. is article analyzed the distribution of different types of HPV in different tissue types of cervical lesions, which played an important role in the prevention, diagnosis, and treatment of cervical cancer
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