Application of human papillomavirus typing detection and cervical vaccine in prevention and treatment of cervical cancer

Abstract

Objective To investigate the application value of typing detection of human papillomavirus (HPV) and cervical vaccine in the prevention and treatment of cervical cancer. Methods A total of 1 450 women aged 35-60 years old in Huizhou area from January 2017 to December 2017 were selected as research subjects. According to the histological examination, enrolled patients were divided into healthy group, chronic cervicitis group, cervical intraepithelial neoplasm (CIN) Ⅰ group, CIN Ⅱ group and CIN Ⅲ group. All patients underwent HPV typing test. HPV infection condition in different age groups and HPV infection condition in patients with different grades of cervical lesion were analyzed. Results A total of 352 patients were found with HPV infection, and the detection rate of HPV was 24.3%. The increase in age was positively correlated with HPV infection rate. The infection rate of HPV would increase with ages, and there was a significant difference in HPV infection rate among different age groups (P<0.05). The HPV infection rate would increase with increase in degree of cervical lesion, which indicated importance of regular cervical cancer screening for sexually active women. There were significant differences in HPV infection rate between cervical lesions of different grades (P<0.05). Conclusions The combined application of HPV typing test and cervical vaccine is conducive to the fluent progress of screening cervical cancer, and it can provide important reference basis for the prevention and treatment of cervical cancer. Key words: Human papilloma virus; Cervical vaccine; Cervical cancer; Prevention and control; Effect