Analysis of distribution and drug resistance of bacteria in 1-6 months infants with lower respiratory infection

Abstract

Objective To investigate the distribution and drug resistance of bacteria in 1-6 months infants with lower respiratory infection(LRI). Methods Induced sputum was extracted from 326 infants with LRI who were 1-6 months. Antibiotic susceptibility tests were performed after bacteria had been identified. Results 61 cases were detected pathogenic bacteria and the detection rate of bacteria was 18.71%.5 cases were detected two kinds of bacteria. 66 bacterial strains were isolated among which gram-positive bacteria(33 strains)accounted for 50.00%and gramnegative bacteria(33 strains)accounted for 50.00%. Staphylococcus aureus was the most common gram-positive bacteria and Streptococcus pneumoniae was the second.13 strains were methicillin-resistant Staphylococcus aureus(MRSA). Hemophilus influenzae was the most common gram-negative bacteria,followed by Klebsiella pneumonia and Escherichia coli among which ESBL positive Klebsiella pneumonia were 5 cases and ESBL positive Escherichia coli were 4 cases.The common gram-positive bacteria had higher rate of penicillin resistance.MRSA had higher rate of penicillin,oxacillin, erythomycin and clindamycin resistance. Resistant strains to vancomycin and rina thiazole amine were not found. The common gram-negative bacteria had higher rate of ampicillin, ampicillin/shu tan, cefazolin and ceftriaxone resistance and had lower rate of cefepime, ceftazidime, piperacillin/he azole temple and imipenem resistance. Conclusion The common pathogenic bacteria in 1-6 months infants with lower respiratory infection were Staphylococcus aureus, Hemophilus influenzae, Streptococcus pneumoniae, Klebsiella pneumonia and Escherichia coli. We should pay attention to the common antibiotic resistance. MRSA and ESBL positive bacteria were the common multiple drug resistant bacterias. Reasonable selection of antibiotics should be based on susceptibility results earlier. Key words: Respiratory Tract Infections; Bacteria; Noxae; Drug Resistance, Bacterial; Infant