Analysis of diagnosis and prognosis of MRP8/14 on prostate cancer

Abstract

Objective To compare the MRP8/14 level in Normal people, benign prostatic hyperplasia(BPH) patient and prostate cancer patient, and explore the relationgship between MRP8/14 and prostate cancer. Methods 150 cases of normal people, 150 cases of BPH patients and 150 cases of prostate cancer patients were chose from December 2012 to December 2014 in our hospital. ELISA method was used to detect the MRP8/14 level in each group. ROC cure was used to analyse the prediction value of MRP8/14 for prostate cancer. According to the cut off value of MRP8/14, prostate cancer patients were divided into MRP8/14 low value group (MRP8/14<cut off value) and MRP8/14 high value group (MRP8/14≥cut off value), and the difference of patient's clinical characteristics and survival function between high value group and low value group were explored. Results The MRP8/14 level of normal people was (966.7±152.8)ng/ml, while the BPH patient was (1 207.0±190.6)ng/ml, and the prostate cancer patient was (2 833.3±1 101.5)ng/ml, the difference is statistically significant. ROC analysis resμlt showed that the AUC for the prediction of prostate cancer was 0.887(95%CI 0.841-0.934), with a high statistical significance, indicating that MRP8/14 may possess high prediction value for prostate cancer. In addition, the cut off value was 2 845.682 ng/ml, with the specifity of 76.4% and sensitivity of 85.1%. According to the cut off value of MRP8/14, prostate cancer patients were divided into the low MRP8/14 group ( 2 and tumour stage>Ⅲ were much more in MRP8/14 high value group. PSA level, LDH level, AKP level, CRP level and Alkaline Phosphatase level were also significantly increased in MRP8/14 high value group. Besides, prostate cancer patient with an average follow-up of 2 years, a total of 32 cases of patients died, 12 cases in the MRP8/14 low value group with mortality of 13.6%, 20 cases in MRP8/14 high value group with mortality of 32.3%. Kaplan Meier survival function curve shows 2 years survival rate of patients in high value group was significantly reduced. Cox regression analysis showed that MRP8/14 was possible risk factors associated with mortality, and the independent predictors for all-cause mortality during follow-up. Conclusion MRP8/14 was significantly increased in prostate cancer patients, and it was an independent predictor of 2-year mortality in prostate cancer patients. Key words: Myeloid-related protein 8/14; Prostate cancer; Prognostic; Clinical significance