Abstract
Analysis of Cytotoxic Effects of Chemotherapeutic Agents for Gastrointestinal Cancer with Cell-based Impedance Biosensor
Highlights
Gastrointestinal cancer is one of the most commonly diagnosed cancers, and one of the highest causes of cancer death for both men and women.[1,2,3,4] It was reported that there were more than 49000 deaths due to gastrointestinal cancer in the United States in 2016.(5,6) in the majority of these patients, the disease was in an advanced state at the time of diagnosis
Clinical studies showed that both compound Kushen injection (CKI) and cinobufacini injection could attenuate the side effects of chemotherapy and radiotherapy, improving the quality of life.[18,19] Growth factors, such as transforming growth factors-β (TGF-βs) and fibroblast growth factors (FGFs), are secreted polypeptides and are involved in a variety of important cellular functions, including cell proliferation, differentiation, and apoptosis.[15,20,21] detecting the impacts of these reagents on different cancer cells could provide a new way to explore the mechanism of cancer therapy
Culture medium on electrodes is equivalent to a simple circuit containing a solution resistance (Rs) and a constant phase element (CPE) [Fig. 2(a)]
Summary
Gastrointestinal cancer is one of the most commonly diagnosed cancers, and one of the highest causes of cancer death for both men and women.[1,2,3,4] It was reported that there were more than 49000 deaths due to gastrointestinal cancer in the United States in 2016.(5,6) in the majority of these patients, the disease was in an advanced state at the time of diagnosis. Clinical studies showed that both CKI and cinobufacini injection could attenuate the side effects of chemotherapy and radiotherapy, improving the quality of life.[18,19] Growth factors, such as transforming growth factors-β (TGF-βs) and fibroblast growth factors (FGFs), are secreted polypeptides and are involved in a variety of important cellular functions, including cell proliferation, differentiation, and apoptosis.[15,20,21] detecting the impacts of these reagents on different cancer cells could provide a new way to explore the mechanism of cancer therapy
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