Abstract
Among 371 patients with colorectal cancer experienced at our department from 1973 to 1989, fifty-seven with synchronous liver metastasis and 17 with metachronous ones whose lesions, namely, were found postoperatively, were subjected to clinicopathological analysis to clarify characteristicts of the liver metastasis colorectal cancer. The patients group comprised 51 males and 23 females, with an average of 64.7 years. The primary tumors were commonly found in the rectum (49%) and sigmoid colon (26%). In the rectum it was predominant in Ra. Macroscopically type 2 cancer and histologically well differentiated adenocarcinoma were predominant. Subserosa (a1) type in the depth of wall invasion accounted for 67%. Averaged survival periods by the degree of hepatic involvement were 42.7 months in H0, 15.9 months in H1, 14.2 months in H2, and 7.4 months in H3. A clear correlation between the time when liver metastasis occurred and the prognosis was suggested. To gain better prognosis for colorectal cancer with liver metastasis, agressive intra-arterial infusion chemotherapy and resection of hepatic metastasized lesion are recommended.
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