Analysis of changes of sleep and glucose metabolism in patients with OSAHS before and after nasal continuous positive airway pressure ventilation

Abstract

Objective To investigate the changes of sleep and glucose metabolism in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) after nasal continuous positive airway pressure (nCPAP) before and after the intervention. Methods Eighty-six patients with OSAHS who received treatment in our hospital during the period from June 2012 to September 2015 were randomly divided into observation group and control group, each of 43 cases.The patients in the observation group were treated with nasal continuous positive airway pressure, and the control group were given routine treatment.Sleep and sugar metabolism were compared between the two groups before and after treatment. Results After 3 months of intervention, the apnea hypopnea index (AHI) in the observation group was (15.38±4.66) times/h, lower than that in the group before intervention and that in the control group after 3 months of intervention (t=12.194, P=0.000, t=14.453, P=0.000). The longest duration of apnea was (24.53±10.74) s, shorter that in the group before intervention and that in the control group after 3 months of intervention (t=8.524, P=0.000, t=7.450, P=0.000). After 3 months of intervention, the AHI in the observation group was (3.64±1.02) times/h, lower than that in the group before intervention and that in the control group after 3 months of intervention (t=12.531, P=0.000, t=13.105, P=0.000) and ESS score (5.86±1.17) was also lower than that in the group before intervention and that in the control group after 3 months of intervention (t=14.964, P=0.000, t=13.022, P=0.000). After 3 months of intervention, the FBG in the observation group was (6.38±0.96) mmol/L, lower than that in the group before intervention and that in the control group after 3 months of intervention (t=9.193, P=0.000, t=6.590, P=0.000). HbA1c [(6.53±1.62)%] was also lower than that in the group before intervention and that in the control group after 3 months of intervention (t=5.847, P=0.000, t=5.339, P=0.000). Conclusions nCPAP can effectively improve the quality of sleep and abnormal glucose metabolism in OSAHS patients, and reduce the risk of diabetes. Key words: Nasal continuous positive airway pressure; Obstructive sleep apnea hypopnea syndrome; Sleep; Glucose metabolism