ANALYSIS OF CHANGES OF MULTIPLE ORGAN FAILURE FORMATION DEPENDING ON THE TERMS OF SURGICAL TREATMENT OF SEVERE BURNS

Abstract

Oxygen imbalance on the tissue level is the main reason for homeostasis disorders and development of multiple organ failure as a severe complication after severe burns. The issues of influence on the microcirculatory system and the consequences of its damage remain topical and free-answered. The objective of this work was the comparative analysis of the dynamics of changes of multiple organ failure formation depending on the term and beginning of surgical treatment of severe burns.105 patients with a thermal trauma were examined and analyzed. To determine severity of thermal damage all the patients were assessed for injury severity index (ISI), the area of deep burn (ADB, %), a general area of burn (GAB, %), the age of a patient, and the presence of respiration system burn. According to ISI all the patients were divided into the groups of research. The 1st group included 46 injured with the ISI from 61 to 90 units. The 2 group counted 29 patients with the ISI index over 91 units. According to the terms of surgery, patients of these groups were divided into sub-groups: 1.1 and 2.1, where the first surgery was performed in less than five days of burn disease; 1.2 and 2.2, where the first surgery was performed after five days of burn disease. The scale SOFA was used to assess the risk of developing morbidity and mortality associated with sepsis. The diagnostic-therapeutic program was conducted according to the clinical protocol of medical aid given to injured individuals with thermal trauma. Against the ground of the performed intensive therapy during the acute period of burn disease the dependence of multiple organ failure formation on the time of the surgery beginning was not found.