Analysis of Changes of Intestinal Flora in Elderly Patients with Alzheimer's Disease and Liver Cancer and Its Correlation with Abnormal Gastrointestinal Motility.

Weiwei Zhang,Huanyu Wu,Yunxia Meng,Xinyu Zhou,Yanyan Zhang,Xuelian Zhang,Qiaoling Liu,Muhammad Wasim Khan

doi:10.1155/2021/7517379

Weiwei Zhang, Huanyu Wu + Show 6 more

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https://doi.org/10.1155/2021/7517379

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Abstract

Objective To investigate the changes of intestinal flora in elderly patients with Alzheimer's disease and liver cancer and its correlation with abnormal gastrointestinal motility. Methods From January 2018 to December 2020, 102 elderly patients with Alzheimer's disease and liver cancer were selected as the observation group. Eighty-nine healthy patients during the same period were selected as the control group. The two groups of intestinal flora (intestinal microbial diversity) were detected by real-time fluorescent quantitative PCR (RT-qPCR) and high-throughput sequencing. The two groups of serum motilin (MTL) and gastrin (GAS) levels were measured by the Hitachi automatic biochemical analyzer 7600. Pearson correlation analysis software was used to analyze the relationship between changes in the intestinal flora and gastrointestinal motility in elderly patients with Alzheimer's disease and liver cancer. Results The contents of Bifidobacteria and Lactobacilli in the observation group were lower than those in the control group, and the contents of Escherichia coli, Helicobacter pylori, and Streptococcus were higher than those in the control group. The Chaol index and Shannon index in the observation group were higher than those in the control group. The gastrointestinal motility levels MTL and GAS of the observation group were higher than those of the control group. The results of Pearson correlation analysis showed that the Chaol index and Shannon index of elderly patients with Alzheimer's disease and liver cancer were positively correlated with MTL and GAS. Conclusion Elderly patients with Alzheimer's disease and liver cancer often have changes in the intestinal flora, which are correlated with abnormal gastrointestinal motility. Strengthening the analysis of changes in patients' intestinal flora can enhance clinical medication knowledge and improve gastrointestinal motility in patients.

Highlights

Alzheimer’s disease is a degenerative disease of the nervous system with relatively insidious onset and progressive development in the elderly. e clinical manifestations are memory impairment, aphasia, ignorance, impairment of visual and spatial skills, and executive dysfunction [1]
Liver cancer is a malignant tumor that occurs in the liver, and its incidence is mainly related to viral hepatitis, drinking, eating moldy food, and heredity. e clinical symptoms in the early stage of the disease lack typicality, and as the course of the disease prolongs, they usually manifest as pain, fever, and fatigue in the liver area
From January 2018 to December 2020 at the First People’s Hospital of Lianyungang, Lianyungang, China, 102 elderly patients with Alzheimer’s disease and liver cancer were selected as the observation group and 89 cases of healthy physical examination during the same period were included in the control group. ere was no statistically significant difference in the general information of the two groups of patients, and they were comparable (Table 1). e study was approved by the ethics committee of the First People’s Hospital of Lianyungang, Lianyungang, China, and the patient’s informed consent was obtained

Summary

Introduction

Alzheimer’s disease is a degenerative disease of the nervous system with relatively insidious onset and progressive development in the elderly. e clinical manifestations are memory impairment, aphasia, ignorance, impairment of visual and spatial skills, and executive dysfunction [1]. Alzheimer’s disease is a degenerative disease of the nervous system with relatively insidious onset and progressive development in the elderly. Current studies show that the onset of Alzheimer’s disease in the elderly may be related to family history, head trauma, viral infection, etc., but its specific pathogenesis is still not clear. With the increasing aging of the population in China, elderly Alzheimer’s disease incidence is on the rise [2, 3]. E clinical symptoms in the early stage of the disease lack typicality, and as the course of the disease prolongs, they usually manifest as pain, fever, and fatigue in the liver area. Previous studies have shown that intestinal flora belongs to the “second genome” of the human body and is an important defense line of the body’s immune system [4].

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