Abstract
BackgroundTo explore the effect of dexmedetomidine (Dex)-assisted intravenous anesthesia on gastrointestinal motility in patients with colon cancer (CC) after open colectomy.MethodsA total of 102 patients with CC, undergoing open colectomy in our hospital from January 2018 to January 2020, were selected and randomly divided into an observation group (n = 51) and a control group (n = 51). The patients in the control group received a routine combination of intravenous and inhalation anesthesia (CIIA), while those in the observation group received a Dex-assisted CIIA. The systolic blood pressure (SBP), the diastolic blood pressure (DBP), heart rate (HR), and the mean arterial pressure (MAP) were compared at different time points between the two groups. In addition, the intraoperative general conditions, the dosage of anesthetics, and the recovery of gastrointestinal functions were also compared between the two groups. Moreover, before operation and at 24 h after operation, the levels of serum gastrin (GAS) and plasma motilin (MTL) were detected by radioimmunoassay, and the level of plasma cholecystokinin (CCK) was detected by an enzyme-linked immunosorbent assay. The incidence of gastrointestinal complications was recorded in both groups.ResultsAt T1-T3, the HR, SBP, DBP, and MAP levels were lower in both groups than those at T0. In addition, they were also lower in the observation group than those in the control group, showing significant differences (p < 0.05). The dosage of propofol and remifentanil in the observation group was lower than that in the control group, and there was a significant difference (p < 0.05). In the observation group, the postoperative first exhaust time, first defecation time, first ambulation time, and first feeding time were all earlier than those in the control group with significant differences (p < 0.05). After the operation, the observation group had higher levels of GAS and MTL but a lower level of CCK than the control group, and the differences were significant (p < 0.05). The incidence rate of gastrointestinal complications in the observation group (7.04%) was lower than that in the control group (19.61%), and there was a significant difference (χ2 = 4.346, p < 0.05).ConclusionsDex-assisted intravenous anesthesia can facilitate the recovery of gastrointestinal motility, can regulate the levels of gastrointestinal hormones, and can stabilize the levels of hemodynamic indexes in patients with CC after open colectomy.
Highlights
Colon cancer (CC) is a digestive tract malignancy that frequently occurs at the junction of the rectum and the sigmoid colon [1]
The inclusion criteria were as follows: [1] patients meeting the diagnostic criteria for CC [9] and confirmed by the clinical-pathological examination; [2] those undergoing open colectomy; [3] those in American Society of Anesthesiologists (ASA) classes I-II and TNM stages I-II; [4] those who are not undergoing preoperative radiotherapy and chemotherapy; [5] those with an expected survival time >3 months; and 6) those who and whose families were fully informed of this study and had signed the informed consent
Colon cancer (CC) is a gastrointestinal tract malignancy derived from the colonic mucosal epithelium, manifested as varying degrees of abdominal distension, indigestion, and changes in defecation habits in most patients [12]
Summary
Colon cancer (CC) is a digestive tract malignancy that frequently occurs at the junction of the rectum and the sigmoid colon [1]. It clinically manifests as abdominal pain, abdominal masses, changes in defecation habits, anemia, and gastrointestinal irritation and causes intestinal obstruction and intestinal perforation [2]. Dexmedetomidine (Dex) is a novel selective α2adrenergic receptor agonist characterized by high intrinsic activity and short half-life [5]. It can inhibit the release of catecholamines and sympathetic nervous excitability in the central sympathetic nervous system, without respiratory depression. To explore the effect of dexmedetomidine (Dex)-assisted intravenous anesthesia on gastrointestinal motility in patients with colon cancer (CC) after open colectomy
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