Abstract

Objective To study the change and significance of peripheral blood T-lymphocyte subsets in patients with retreatment pulmonary tuberculosis.Methods A total of 120 patients with tuberculosis in branch hospital of infectious diseases of the second people' s hospital of Changshu from August 2009 to January 2012,including 78 males and 42 females,aged from 22 to 85 years (average 57 years),were included in this study.The patients were divided into retreatment pulmonary tuberculosis group (60 cases) and initial treatment pulmonary tuberculosis group (60 cases).Furthermore,the 60 patients with retreatment pulmonary tuberculosis were divided into different subgroups according to the lung fields involved and phlegm mycobacterium tuberculosis check results:Patients with involvement of 1-2 lung fields (26 cases),vs 3-4 lung fields (14 cases) and 5-6 lung ficlds(20 cascs),patients with phlegm positive check results (34 cases) vs phlegm negative check results (26 cases).Peripheral blood T-lymphocyte subsets (by fiow cytometry doubled-labeled antibody) were determined and analyzed in 120 patients.Results The levels of peripheral blood CD4 +/CD8 + in patients with retreatment pulmonary tuberculosis were significantly lower than those in initial treatment pulmonary tuberculosis patients (1.7 ±0.6 and 2.0 ±0.8,respectively,t =-2.813,P ＜0.05).The levels of peripheral blood CD4 +/CD8+in patients with 5-6 lung fields retreatment pulmonary tuberculosis were significantly lower than those in patients with 1-2 lung fields retreatment pulmonary tuberculosis(1.6 ±0.7 and 2.1 ±0.6,respectively,F =4.000,P ＜ 0.05).Conclusions Patients with retreatment pulmonary tuberculosis have lower cellular immune function compared to those with initial treatment pulmonary tuberculosis,and the cellular immune function is significantly correlated with the extent of pulmonary lesions.All of the above indicate that it is necessary to consider immune regulators as supportive treatment for retreatment pulmonary tuberculosis. Key words: Pulmonary tuberculosis; Retreatment; Cellular immune function

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