Analysis of Artifactual Components Rejection Threshold towards Enhanced Characterization of Neural Activity in Post-Stroke Survivor.

Abstract

Research advancement has spurred the usage of electroencephalography (EEG)-based neural oscillatory rhythms as a biomarker to complement clinical rehabilitation strategies for the recovery of motor functions in stroke survivors. However, the inevitable contamination of EEG signals with artifacts from various sources limits its utilization and effectiveness. Thus, the integration of Independent Component Analysis (ICA) and Independent Component Label (ICLabel) has been widely employed to separate neural activity from artifacts. A crucial step in the ICLabel preprocessing pipeline is the artifactual ICs rejection threshold (TH) parameter, which determines the overall signal's quality. For instance, selecting a high TH will cause many ICs to be rejected, thereby leading to signal over-cleaning, and choosing a low TH may result in under-cleaning of the signal. Toward determining the optimal TH parameter, this study investigates the effect of six different TH groups (NO-TH and TH1-TH6) on EEG signals recorded from post-stroke patients who performed four distinct motor imagery (MI) tasks including wrist and grasping movements. Utilizing the EEG-beta band signal at the brain's sensorimotor cortex, the performance of the TH groups was evaluated using three notable EEG quantifiers. Overall, the obtained result shows that the considered THs will significantly alter neural oscillatory patterns. Comparing the performance of the TH-groups, TH-3 with a confidence level of 60% showed consistently stronger signal desynchronization and lateralization. The correlation result shows that most of the electrode pairs with high correlation values are replicable across all the MI tasks. It also revealed that brain activity correlates linearly with distance, and a strong correlation between electrode pairs is independent of the different brain cortices. The study outcome may facilitate adequate therapeutic intervention for stroke rehab.Clinical Relevance: This study indicated that optimal selection of the ICLabel artifactual rejection threshold is essential for EEG enhancement for adequate signal characterization. Thus, a TH-values with a confidence level between 50% - 70% would be suggested for artifactual ICs rejection in MI-EEG.