Abstract
The antimicrobial and antioxidant potential of Chenopodium ambrosioides L. was explored. Antimicrobial potential was investigated through zone of inhibition and minimum inhibition concentration whereas antioxidant potential of selected plant was evaluated through different techniques, that is, total phenolic contents, total flavonoids content, DPPH assay, ABTS assay, and metal chelating. It is concluded that both parts showed good to satisfactory antimicrobial and antioxidant results. The maximum antibacterial potential is exhibited by bark macerated in petroleum ether against Bacillus subtilis (33±1.5 mm) and maximum antifungal potential exhibited by methanol extracts of fruit against Aspergillus niger (16±1.5 mm). Aqueous extracts failed to show any activity against selected organisms. The minimum (significant) MIC value exhibited by fruit extract against Staphylococcus aureus was 0.009±0.02 at 0.7 mg/mL. Aqueous extracts of bark and fruit exhibited maximum antioxidant potential in all assays except DPPH assay. Petroleum ether bark extract showed maximum % DPPH value.
Highlights
Plant constituents have broad spectrum in provision of their biological properties and structure and become a source of active natural products
Through xanthene oxidase activity and liver mixed function, free radicals are produced as a result of the normal metabolic process and free radical chain reactions usually occurring as respiratory chain reaction
Peroxidation of lipids can be initiated by the oxygen free radical, which in turn stimulates the glycation of protein, inactivation of some enzymes, and modification in the function and structure of collagen basement and a few other membranes, and play a role in chronic impediment of diabetes [2]
Summary
Plant constituents have broad spectrum in provision of their biological properties and structure and become a source of active natural products. Many disorders such as cancer and cardiovascular diseases are prevented by plants beverages, fruits, and vegetables because they are rich in natural antioxidant compounds. Numerous compounds are present in plants which have diverse mechanism of action that includes some enzymes, protein, and secondary metabolites, for example, carotenoids, vitamins, flavonoids, anthocyanins, and other phenolic components which is the foundation of antioxidant and antimicrobial potential of plant products [1]. Peroxidation of lipids can be initiated by the oxygen free radical, which in turn stimulates the glycation of protein, inactivation of some enzymes, and modification in the function and structure of collagen basement and a few other membranes, and play a role in chronic impediment of diabetes [2]
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