Abstract
Spontaneous bacterial peritonitis (SBP) is a bacterial infection of ascitic fluid in patients with decompensated cirrhosis. Factors influencing the development of SBP are poorly understood but clinical and experimental data suggest that peritoneal macrophages contribute to the control of SBP. MCP–1 is a potent chemokine and a functional polymorphism in the promoter region of the MCP–1 gene (A–2518G) was found to confer increased MCP–1 expression. Here, we investigated this polymorphism in patients with SBP.
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