Abstract
To formulate efficient drug delivery systems by a suitable supercritical method, the solubility of drugs in the supercritical solvent like supercritical carbon dioxide (scCO2) must be determined. In this study, solubility of Levetiracetam, a well-known antiepileptic drug, in scCO2 was studied at 308 to 338 K and 120 to 300 bar. It was obtained between the mole fractions of 2 × 10−5 to 3.05 × 10−4 and 0.03 to 0.96 kg.m−3. Also, this process was modelled using various theoretical models (empirical (Chrastil, Bartle, Kumar and Johnston (KJ) and Mendez-Santiago-Teja (MST)), PC-SAFT, SRK, and modified Wilson). All the models show the acceptable results and the deviation among the experimental and model-calculated data are satisfactory. Among them, the optimized Wilson’s model (AARD% = 6.66) and the empirical model proposed by Bartle (AARD% = 13.96) show the highest and the lowest precision, respectively. Also, the total mixing, evaporation, and solvation thermal enthalpies for the Levetiracetam- scCO2 system are computed using the empirical models.
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