Abstract
Abstrak – Cancer is a dangerous disease which is one of the main causes of death in the world, which is 8.8 million deaths in 2015. A new method has been developed for the treatment of cancer with small side effects, Boron Neutron Capture Therapy (BNCT). BNCT is based on the ability of non-radioactive isotopes Boron-10 to capture thermal neutrons. Boron is the main key of the BNCT process wherein, radiation of cancer cells can be carried out selectively if the cancer contains high concentrations of boron. Boron doses in cancer cells cannot be measured directly, therefore artificial network methods are used to compute doses computationally, namely the Monte Carlo method with the Particle and Heavy Ion Transport Code System (PHITS) program. Boron dose used was 10, 20 and 30 ?g/g. It was found that the greater the boron dose the greater the number of neutrons absorbed. The results showed that the largest absorption dose occurred in the Gross Tumor Volume (GTV) area of ??7.7076E-10 Gy/cm2.
 Key words: Cancer, BNCT, Dose of Boron, PHITS.
Highlights
The results showed that the largest absorption dose occurred in the Gross Tumor Volume (GTV) area of 7.7076E-10 Gy/cm2
Belanda: The European Boron Neutron Capture Therapy (BNCT) Project. [16] Sato, T. dkk., 2017, Recent Improvements of Particle and Heavy Ion Transport code System: Particle and Heavy Ion Transport Code System (PHITS), EPJ Web of Conferences 153, 06008 (2017), ICRS-13 & RPSD-2016
Summary
Pada dosis tertentu Boron tidak bersifat toksik sehingga aman jika terakumulasi di dalam tubuh [10]. Dosis Boron (DB) yaitu dosis Boron-10 yang berinteraksi dengan neutron termal, seperti diperlihatkan pada persamaan reaksi (1). B. Dosis gamma (D ) yaitu dosis gamma yang dihasilkan dari interaksi neutron termal dengan hidrogen dalam tubuh. C. Dosis radiasi proton (Dp) yaitu dosis radiasi proton yang diperoleh dari interaksi neutron termal dengan nitrogen dalam tubuh. Kode-kode simulasi tersebut dapat digunakan untuk mensimulasikan hampir semua jenis partikel diantaranya neutron, proton, ion berat, foton, dan elektron, dalam kisaran energi yang luas dengan tingkat energi hingga 1 TEV (per nukleon untuk ion) [9, 16]. Particle and Heavy Ion Transport Code System adalah suatu alat penting yang digunakan di berbagai bidang penelitian seperti perisai radiasi dan perlindungan radiologi pada Fisika Medis.
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