Analyses of Protein Interaction Networks Using Computational Tools.

Abstract

The knowledge of protein-protein interactions (PPIs) and PPI networks (PPINs) is the key to starting to understand the biological processes inside the cell. Many computational tools have been designed to help explore PPIs and PPINs, such as those for interaction detection, reliability assessment and interaction network construction. Here, the application of computational tools is reviewed from three perspectives: PPI database construction, PPI prediction, and interaction network construction and analysis. This overview will provide researchers guidance on choosing appropriate methods for exploring PPIs.