Abstract
Objective This study aimed to evaluate bone regeneration capacity of FDBX granules compared to composite DBBM/DFDBX granules for filling of bone defect in rabbit mandible. Material and Methods Critical size defects were created in 45 rabbits' mandible. The defect in the control group is left untreated, while in other groups the defects were filled with FDBX granules and composite DBBM/DFDBX granules, respectively. Specimens were collected at 2, 4, and 8 weeks for histology and immunohistochemical analyses. Significant difference is set at p -value < 0.05. Results The osteoblast-osteoclast quantification, osteoblast expression of Runx2, alkaline phosphatase, collagen-I, and osteocalcin, and osteoclast expression of receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) in FDBX groups were statistically comparable ( p > 0.05) with the composite group, while OPG/RANKL ratio, bone healing scores, and trabecular area were significantly higher ( p < 0.05) in the composite compared to FDBX group. Conclusion Composite DBBM/DFDBX granules, within the limitation of this study, has better bone forming capacity than FDBX granules for filling of bone defects in the mandible.
Highlights
The demand for bone graft substitutes in implant treatment has increased a great deal for the past decades
This study aimed to evaluate bone regeneration capacity of FDBX granules compared to composite deproteinized bovine bone mineral (DBBM)/DFDBX granules for filling of bone defect in rabbit mandible
Autogenous or allogeneic bone particulate remains the gold standard bone graft for alveolar bone augmentation associated with dental implant treatment
Summary
The demand for bone graft substitutes in implant treatment has increased a great deal for the past decades. Human bonederived particles such as freeze-dried bone allograft (FDBA). Have been used as osteoconductive particles while demineralized FDBA (DFDBA) has been applied due to its osteoinductive properties.[1] human bone products processed by tissue bank has typical problem of lack in donor supply. Bone Regeneration Capacity of Bovine-Bone Filler Kamadjaja et al
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