Abstract
Based on a single-compartment model, an analog computer program was developed which utilizes both analog and logic components of a general-purpose hybrid computer. The program permits the simulation of the blood and urine levels that would be obtained following the administration of an initial dose followed by a series of additional doses. The magnitude of the doses, as well as the time period between doses, may be varied independently. The program can be used to aid the formulator in establishing the amount of drug that should be released during selected time periods from a timed-release dosage form to provide uniform blood levels.
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