Abstract
Opioid and non-narcotic analgesics, non-steroidal anti-inflammatory agents, anesthetics, antidepressants, myorelaxants, combined agents and phytopreparations are widely used for the treatment of pain syndrome. One of the promising phytogenic objects with potential analgesic properties is the Acorus calamus (Sweet Flag).
 The aim: the purpose of the study is to determine the analgesic effect of the dealcoholized extract of Acorus calamus leaves (DEAL) on a model of pain in the "Hot plate" test and in the test of tail heat immersion.
 Materials and methods. During the experimental study, the pharmacological methods have been used. The analgesic properties of DEAL were studied in mice on the "Hot plate" model using the Hot / Cold Plate (Bioseb, France) and in the test of the heat immersion in rats.
 The results. On the models of pain in the "Hot plate" and tail heat immersion tests, the analgesic effect of the dealcoholized extract of Acorus calamus leaves (DEAL) is determined. On the "Hot plate" model, the use of DEAL probably increased the duration of the latency period. According to the analgesic effect of DEAL and metamizol sodium were comparable to each other continues to 1 and 1.5 hours of experiment, but starting with 2 hours of experiment the analgesic action of metamizol sodium statistically exceeded the analgesic effect of DEAL.
 In the test of heat immersion tail in rats, DEAL increased the latency period of shocking of the rats’ tail compared to the starting background by 43.13 % as well as metamizol sodium by 66.6 %. The studies have shown the presence of moderate analgesic effects of DEAL in the investigated dose.
 Conclusions. The analgesic effect of a dealcoholized extract of Acorus calamus leaves (DEAL) on a model of pain in the "Hot plate" and heat tail immersion tests has been carried out. Under the "Hot plate" test in mice, DEAL produces a distinct analgesic effect, however, slightly inferior to the severity of metamizol sodium. Presence of moderate analgesic properties of DEAL has been verified in comparison with the metamizel sodium in thetail heat immersion test in rats. The obtained results indicate the influence of DEAL on the central mechanisms of pain formation
Highlights
One of the most common symptoms in medicine is pain
The aim of the research was to determine the analgesic effect of dealcoholized extract of Acorus calamus leaves (DEAL) on the model of pain in the test "hot plate" and in the test of thermal immersion of the tail
The central mechanisms of analgesic action of DEAL were studied in mice on the model "hot plate" [22,23,24] using the device Hot / Cold Plate (Bioseb, France)
Summary
One of the most common symptoms in medicine is pain. Pain occurs when exposed to nociceptive factors or as a result of suppression of the antinociceptive system [1,2,3]. Chronic pain of various genesis, which affects one in five, is quite common [5, 6]. Are widely used for the treatment of pain syndrome [7]. Herbal medicines are widely used in the treatment of pain, because according to the "WHO Strategy for Folk Medicine 2014–2023", it is indicated that about 80 % of the world's population uses herbal medicines [8]. This is due to the fact that the rich composition of plant BAS provides polyvalence of pharmacological effects [9]. This allows you to achieve maximum severity of the main therapeutic effects, i. e. gently and safely affect many systems of the body, which are somehow involved in the pathological process [10]
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