Abstract
Objective: To assess whether preoperative pentazocine can reduce intraoperative hemodynamic changes and postoperative pain.Methods: Fifty patients undergoing laparoscopic cholecystectomy were randomized into two groups. Group P received intravenous 0.5 mg/kg pentazocine 10 min before surgery, and Group C received normal saline as a placebo. A standardized general anesthesia was conducted in all patients. Mean blood pressure (MBP), heart rate (HR), and visual analog scale (VAS) scores at various time points were recorded. The tramadol consumption during the study period was recorded.Results: Group P had lower VAS scores at two, four, and eight hours postoperatively compared with Group C. MBP and HR rose significantly because of pneumoperitoneum within Group C, and no significant changes were detected in MBP and HR within Group P. Tramadol doses given were statistically fewer in Group P.Conclusion: Preoperative intravenous pentazocine can decrease intraoperative hemodynamic changes and postoperative pain.
Highlights
Laparoscopic surgery is associated with less tissue damage than open surgery, intraoperative stress reaction and postoperative pain are still common
We designed this clinical research to assess the analgesic efficacy of preoperative intravenous pentazocine for laparoscopic cholecystectomy under general anesthesia
After approval of the Institutional Ethics Committee of the First Hospital of Jilin University and obtaining written informed consent from the participants, this randomized and double-blinded study was conducted on 50 patients undergoing laparoscopic cholecystectomy under a standardized general anesthesia
Summary
Laparoscopic surgery is associated with less tissue damage than open surgery, intraoperative stress reaction and postoperative pain are still common. Various drugs have been used for this analgesic method. Pentazocine, which acts as an agonist of Kappa receptors (κ receptors) and partial agonist/antagonist of M receptors, has been widely used to treat moderate to severe pain. It is recognized that pentazocine has an adequate analgesic efficacy with relatively weak respiratory depression and addiction [1,2]. We designed this clinical research to assess the analgesic efficacy of preoperative intravenous pentazocine for laparoscopic cholecystectomy under general anesthesia
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