Analgesic effect of Butorphanol combined with Dexmedetomidine in patients with traumatic brain injury

Abstract

Objective To observe the analgesic effect of Butorphanol combined with Dexmedetomidine in patients with traumatic brain injury (TBI), providing evidence for clinical treatment of TBI. Methods 60 Patients with TBI admitted to the EICU between January 2018 and May 2018 were included and divided into two groups, the Butorphanol group (30 cases) and the Fentanyl group (30 cases), with a random number table. Patients in the Butorphanol group were treated with Butorphanol plus Dexmedetomidine and those in the Fentanyl group were treated with Fentanyl plus Dexmedetomidine for analgesia and sedation. Clinical indicators including APACHEⅡand GCS scores were recorded and comparatively analyzed for the two groups. Results After treatment, the heart rate, respiration frequency, pain scores and the rate of nutrient retention of the patients in the Butorphanol group were lower than those of the Fentanyl group [(85.51±9.41) times/min vs (114.63±12.23) times/min, (23.41±3.92) times/min vs (33.87±5.12) times/min, (0.91±0.34) scores vs (2.11±0.39) scores, 10.0% vs 36.7%, all P<0.05] , and the oxygen pressure was higher than that of the Fentanyl group [(96.21±10.51) mmHg vs (74.18±8.54) mmHg, P<0. 05]. No significant differences in other indicators were observed between the two groups. Conclusion Butorphanol combined with Dexmedetomidine is effective in patients with TBI in ICU with favorable analgesic effect and few complications. Key words: Butorphanol; Dexmedetomidine; TBI; Analgesic