Year-end Sale % OFF 
Abstract
Naproxen, a non-steroidal anti-inflammatory drug (NSAID), was complexed with zinc (II) metal. Tests were performed to determine the analgesic, anti-inflammatory and ulcerogenic effects of zinc-naproxen compared with naproxen. Compared with naproxen, on a molar equivalent basis, the zinc-naproxen complex was found to have greater analgesic activity (acetic acid-induced abdominal constriction and tail-flick tests in mice) and comparable anti-inflammatory activity (rat paw oedema). The zinc-naproxen complex was also less ulcerogenic than naproxen in a chronic gastric injury model. Complexation of naproxen with zinc markedly reduces its ulcerogenic effect with better analgesic and comparable anti-inflammatory effects.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
