Analgesic and anti-inflammatory properties of Argyreia argentea methanol extract in animal model

Abstract

Analgesic effect of Argyreia argentea methanol extract was assessed by acetic acid and formalin induced pain in Swiss albino mice. The extract at doses of 1.0, 1.5 and 2.0 g/kg produced an inhibition of 12.66, 16.04 & 23.60% in acetic acid induced pain and 19.3, 24.5 & 31.0% in formalin induced pain. The anti-inflammatory activity of the same extract was estimated volumetrically by measuring the mean increase in hind paw volume of carrageenan-induced Wistar albino rat with plethysmometer. Oral administration of the extract at doses of 1.0, 1.5 and 2.0 g/kg showed a time-dependent (1st, 2nd, 3rd and 4th hour) response in reduction of inflammation where the highest inhibition 25.0, 36.36 and 44.0%, were recorded at the 4th hour of treatment. Diclofenac sodium (40 mg/kg) has been administrated as a positive control in the inhibition of acetic acid and formalin induced pain as well as in carrageenan-induced paw edema. The results demonstrate that the extract could be a new and potential source of anti-inflammatory and analgesic drug.