Abstract
The present study was undertaken to evaluate the analgesic activity of aqueous extract of Citrullus lanatus peels (AECL) using Eddy's hot plate method. The AECL produced a significant analgesic activity in a dose dependent manner. All the doses of AECL (250, 500 and 1000mg/kg) had shown analgesic activity. The reaction time obtained for these three doses after 90 minutes of drug administration was found out to be 5.15 mins, 8.92 mins and 10.82 mins respectively which was comparable to Diclofenac sodium (5 mg/kg) that showed the reaction time of 12.36 mins. It was concluded that the AECL has good analgesic potential and may be adopted as alternative to conventional NSAIDS.
Highlights
Pain has been defined by International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience associated with actual or potential tissue damage [1]
It has been observed that the risk of gastrointestinal bleeding are significantly associated with acute use of non-steroidal anti-inflammatory drugs (NSAIDs) like regular-dose aspirin, diclofenac, ketorolac, naproxen or nimesulide
The fruit of Citrullus lanatus was purchased from the local commercial market of Jaipur in February month 2012
Summary
Pain has been defined by International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience associated with actual or potential tissue damage [1]. Tissue injury activates primary afferent neurons called nociceptors, which are small diameter afferent neurons (with A-delta and C-fibers) that respond to noxious stimuli and are found in skin, muscle, joints, and some visceral tissues.. Tissue injury activates primary afferent neurons called nociceptors, which are small diameter afferent neurons (with A-delta and C-fibers) that respond to noxious stimuli and are found in skin, muscle, joints, and some visceral tissues.5 These fibers have specific receptors that may be responsible for noxious mechanical, chemical or thermal stimuli. Opioids or nonopioids are the drugs that are currently used for the management of pain All these drugs carry potential toxic effects. Opioids are the commonly used drugs for the management of acute postoperative pain [4]. Gill et al evaluated the antioxidant, anti-inflammatory and analgesic potential of the Citrullus lanatus seeds [5]. The aim of this study was to investigate analgesic potential of aqueous extract of Citrullus lanatus peels
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