Abstract
This study examines the analgesic activities and phytochemical constituents of aqueous leaf extract of Greenwayodendron suaveolens (Engl. and Diels) Verdc. Analgesic activities were evaluated by means of acetic acidinduced writhing reflex and hot plate nociception models. The extract was also screened for presence of secondary metabolites. The plant extract caused 4.21%, 14.00%, 21.10% and 19.10% inhibition to acetic acid induced writhing in a graded dose dependent manner of 100, 200, 400 and 800 mg/kg respectively. It also protected the mice significantly (P<0.05) against thermal induced pain stimulus at a temperature of 55±1 0C. The activity of the extract appears to be mediated by both peripheral and, especially, central routes. Phytochemical screening revealed the presence of saponins, phenols and flavonoids, which may be responsible for the activities of the extract. The study validates the therapeutic use of the plant in the management of pain.Keywords: Analgesic; Phytochemistry; Leaf; Extract; Greenwayodendron suaveolens
Highlights
Greenwayodendron (Annonaceae) is a monophyletic rainforest tree genus endemic to Tropical Africa (Piñeiro et al, 2016)
The filtrate was concentrated over a water bath to obtain a semi-solid paste of G. suaveolens leaf extract (GSLE), which was collected in a clean container, sealed and stored in a refrigerator until further use
Preliminary Phytochemistry: Saponins, phenols and flavonoids are present in the aqueous leaf extract of G. suaveolens, but alkaloid was not detected (Table 2)
Summary
Greenwayodendron (Annonaceae) is a monophyletic rainforest tree genus endemic to Tropical Africa (Piñeiro et al, 2016). The study examines the analgesic activities and phytochemical properties of aqueous extract of the leaves of G. suaveolens. Collection and Preparation of Plant material: Fresh leaves of G. suaveolens were collected from matured stands located in the Faculty of Life Sciences, University of Benin, Benin City, Edo State, Nigeria.
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