Abstract
The onset of analgesia elicited by electrical stimulation of sites in the midbrain reticular formation was studied in cats, using an experimentally produced pain that provides a measurable index of perceived pain intensity. The results showed that the analgesia develops gradually over a period of about five minutes or longer. This period may be due to the time required for recruitment of a critical number of active neurons, or to the release of a neurochemical agent which requires time to exert its effects on adjacent neurons or at more distant neural areas.
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