Abstract
This chapter provides a review on recent advances in the development of bioprocesses for butyric and acetic acids production, highlighting metabolic engineering in strain development and novel bioreactor and separation technologies in process development leading to their commercial applications in the near future. Acetic acid is produced naturally as the sole or main fermentation product by anaerobic homoacetogens and aerobic acetic acid bacteria. Metabolic engineering has been widely used in strain development for industrial fermentation to produce bio-based chemicals and biofuels. Conventional batch fermentation processes for acetic and butyric acid production are limited by low reactor productivity, low product yield, and low final product concentration, making product recovery difficult and the process uneconomical. Current petroleum-based manufacturing processes for acetic acid and butyric acid production use distillation for their recovery and purification.
Published Version
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