Abstract
ABSTRACT Introduction In recent years, the applications of calcium carbonate (CaCO3) nanoparticles (NPs) have gained extensive interest as targeted drug/gene delivery systems to cancerous tissues and cells due to their accessibility, low cost, safety, biocompatibility, pH-sensitivity, and slow biodegradability. Areas covered Drug-loaded CaCO3 NPs (CCNPs) have been reviewed. An updated search on the current state of CCNPs as cancer drug/gene delivery systems with a focus on their special properties including pH-sensitivity, biodegradability, and sustained release performance has been also assessed. Expert opinion Based on the reviewed literature, CCNPs, because of their superior features, will have a great aiding role in safe and efficient cancer treatment in the near future.
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