An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

Everton Freitas De Morais,Adriano Rocha Germano,Roseana De Almeida Freitas,Rodrigo Rodrigues Rodrigues,Deborah Gondim Lambert Moreira,Viviane Alves De Oliveira

doi:10.1155/2017/4395049

Everton Freitas De Morais, Adriano Rocha Germano + Show 4 more

Open Access

https://doi.org/10.1155/2017/4395049

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Abstract

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative for α-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.

Highlights

Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin that usually affects the pleura [1]
Histopathological analysis combined with immunohistochemistry is necessary for diagnostic conclusion [4]
90 cases of SFT of the oral cavity have been reported in the English language literature

Summary

Introduction

Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin that usually affects the pleura [1]. SFT in the oral cavity is rare and shows no specific clinical characteristics for establishment of the diagnosis [3]. Oral SFT preferably affects the buccal mucosa and tongue of female patients in the sixth decade of life. It is a slow-growing, painless well-defined submucosal mass of variable size [4,5,6]. 90 cases of SFT of the oral cavity have been reported in the English language literature. This study reports a case of SFT in the floor of the mouth, an uncommon site, discussing the clinicalpathological and immunohistochemical features used for its diagnosis and comparing the findings with recent literature data

Case Report

Discussion

Findings

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