An unexplored representative of gem-difluoroalkenes`, 1,1,4,4,4-Pentafluorobut-1-ene CF3[sbnd]CH2[sbnd]CH[dbnd]CF2 (HFO-1345czf): Reactivity and functionalization possibilities

Natalia V Pavlenko,Lesya A Babadzhanova,Yurii L Yagupolskii,Sheng Peng

doi:10.1016/j.jfluchem.2022.110083

An unexplored representative of gem-difluoroalkenes`, 1,1,4,4,4-Pentafluorobut-1-ene CF3[sbnd]CH2[sbnd]CH[dbnd]CF2 (HFO-1345czf): Reactivity and functionalization possibilities

Natalia V Pavlenko, Lesya A Babadzhanova + Show 2 more

https://doi.org/10.1016/j.jfluchem.2022.110083

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Journal: Journal of Fluorine Chemistry

Publication Date: Jan 29, 2023

Affiliation: National Academy of Sciences of Ukraine, Institute of Organic Chemistry

#Addition-elimination Reactions #Features Of Behavior + Show 5 more

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Abstract

A new, simple one-pot synthesis of 1,1,4,4,4-pentafluorobut-1-ene CF3CH2CHCF2 (HFO-1345czf) (1) was developed. Reactivity of 1 was evaluated in copper(I)-catalyzed defluoroborylation with the following Suzuki-Miyaura cross-coupling of boryl(monofluoro)alkene and addition-elimination reactions with nucleophiles and electrophiles. Features of the chemical behavior of 1 are discussed.

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