Abstract
Discerning lymphatics from blood vessels using lineage-specific markers has advanced our understanding of tumor lymphangiogenesis. Many studies have demonstrated that the newly formed lymphatics are the result of a dynamic and complex interplay between lymphatic endothelium, tumor cells, secreted growth factors, and inhibitors in the tumor microenvironment. Results provide evidence that lymphatics play an active role in cancer metastasis rather than once thought to be passively invaded by infiltrating tumor cells. The latest discovery of Bracher et al. (2012) further supports a dynamic role for lymphatics-mediated melanoma metastasis to sentinel lymph node prompted by tumor-derived epidermal growth factor.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
