An understanding of interlink of psoriasis with metabolic syndrome- A case control study

Abstract

Psoriasis is a chronically relapsing, inflammatory, autoimmune, genetically mediated, skin disorder. Most often association of psoriasis with metabolic syndrome has been seen. Components of metabolic syndrome like diabetes, hypertension and obesity are oftenly linked with psoriasis therefore it is crucial to understand this interlink and prompt diagnosis and treatment therefore plays important role to reduce the morbidity and mortality. It has been seen that psoriasis is associated with metabolic syndrome and its components, such as obesity, diabetes and hypertension. These phenotypically diverse conditions are found to share similar pathologic changes owing to similar susceptibility genes and genetic loci. Objectives: 1: Selection of clinically diagnosed cases of psoriasis vulgaris attending the Derma OPD; 2: Evaluation of the psoriasis vulgaris patients on different parameters ; 3: Comparision of the cases with age and sex matched control groups; 4: Study the link of psoriasis vulgaris with metabolic syndrome. Study Design: It is Case Control study (100 cases and 100 controls). Results: Our study shows that in comparision to non-psoriatic patients i.e 12 (12%) metabolic syndrome is present in 37 (37%) of the psoriatic patients attending the OPD during the period of Jan 2017 to Dec 2017 i.e 1 year duration.the result is statistically significant (odds ratio (OR) –3-175, Degree of freedom(df)-1,p value-0.002. c 2 -8.772]. Conclusion: Study shows that psoriasis is highly linked with metabolic syndrome and its components. Keywords: Metabolic Syndrome, TNF alpha, Psoriasis, Hyperlipidemia, Hypertension, BMI, Obesity, Interleukins.