Abstract
A method for quantitative assay of chlordiazepoxide is described using a combination of ultraviolet spectrophotometry and the Bratton-Marshall reaction for colorimetric confirmation in the presence of interfering substances. The coefficient of variation for the quantitative ultraviolet screening portion of the tests is 10% and that of the quantitative colormetric confirming test is 11%. The quantitative assay method is linear through the range 0.2 to 3.0 mg% actual blood concentration. No significant interfering substances were found in examination of 41 drugs of toxicologic interest with the exception of oxazepam. Specifically procaineamide and sulfonamides do not interfere. The method is useful both as a confirming method for gas chromatographic assay of chlordiazepoxide, and as a primary assay method for toxicology units not equipped with gas chromatography.
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