Abstract
An overview on the role of autophagy in cancer therapy
Highlights
Autophagy is a highly conserved catabolic process with critical functions in the maintenance of cellular homeostasis under normal growth conditions and in the preservation of cell viability under stress [1]
Autophagy is an intracellular process in which cellular components, such as proteins and organelles, are delivered to the lysosome leading to the degradation and recycling of cytosolic compounds, providing cells with essential amino acids, nucleotides, and fatty acids, that enable production of elements required for energy and macromolecule biosynthesis [2,3]
Autophagy plays an important role as a stress response mechanism to chemotherapeutic drugs and radiation in cancer cells
Summary
Lima and Valdemar Máximo2,3,4* 1Departmento de Biomedicina, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal 2Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal 3Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-135 Porto, Portugal 4Departmento de Patologia, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal aContributed to this work, and should be considered joint first authors
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