An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol.

Joice Nascimento Barboza,Damião Pergentino De Sousa,Renan Oliveira Silva,Jand Venes R Medeiros,Carlos Da Silva Maia Bezerra Filho

doi:10.1155/2018/3957262

Joice Nascimento Barboza, Damião Pergentino De Sousa + Show 3 more

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https://doi.org/10.1155/2018/3957262

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The bioactive compounds found in foods and medicinal plants are attractive molecules for the development of new drugs with action against several diseases, such as those associated with inflammatory processes, which are commonly related to oxidative stress. Many of these compounds have an appreciable inhibitory effect on oxidative stress and inflammatory response, and may contribute in a preventive way to improve the quality of life through the use of a diet rich in these compounds. Eugenol is a natural compound that has several pharmacological activities, action on the redox status, and applications in the food and pharmaceutical industry. Considering the importance of this compound, the present review discusses its anti-inflammatory and antioxidant properties, demonstrating its mechanisms of action and therapeutic potential for the treatment of inflammatory diseases.

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Eugenol (4-allyl-2-methoxyphenol) is a phenolic compound from the class of phenylpropanoids and the main component of clove (Syzygium aromaticum (L.) Merr. & L
Eugenol’s ability to sequester free radicals in the DPPH assay (IC50 = 11.7 μg/mL), as well as to inhibit reactive oxygen species (ROS) (IC50 = 1.6 μg/mL), H2O2 (IC50 = 22.6 μg/mL and 27.1 μg/mL), and nitric oxide (NO) (IC50< 50.0 μg/mL) [36]. These data corroborate with other studies in which eugenol demonstrated DPPH sequestering activity with EC50 of 22.6 μg/mL [37]
This review demonstrates that eugenol exerts a beneficial action on oxidative stress through the inhibition of enzymes and oxidative processes, which is related to the antiinflammatory drug profile of this compound

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Introduction

Eugenol (4-allyl-2-methoxyphenol) is a phenolic compound from the class of phenylpropanoids and the main component of clove (Syzygium aromaticum (L.) Merr. & L. Pan and Dong [51], using an experimental model of allergic asthma induced by ovalbumin (OVA), demonstrated that eugenol administration inhibited the OVA-induced eosinophilia in the lung tissue, prevented the increased of IL-4 and IL-5 levels, and reduced the NF-κB signalizing pathways.

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