An overview on liquisolid technique: its development and applications.

Abstract

With its simplicity and cost-effectiveness, the liquisolid technique offers solutions for numerous formulation problems. Among these are dissolution enhancement and sustaining drug release, and the liquisolid technique dealt with both approaches. This review focuses on the latest advances in the technique. It discusses modified additives for use as carrier materials, which secure the required large surface area for enclosing liquids. The review also covers the modern liquipellet technique derived from the extrusion/palletization technique. Also, the liquiground term is introduced, combining the advantages of co-grinding with the liquisolid concept. Furthermore, several grades of Eudragits, and hydrophilic retarding polymers are mentioned to explain modes of sustaining drug release. This review sums up the liquisolid technique development and its applications recently achieved.