An overview of Transethosomes: Novel nanocarrier for transdermal drug delivery system

Abstract

The Human skin is made of different layers and the skin will act as a barrier `and it allows the delivery of the drugs through it which is known as TDDS. The delivery of the drug through the epidermis layer of the stratum corneum is difficult as it never allows large particle-sized molecules through it. So there is a need to decrease the particle size and it can be done with new advancements in transdermal delivery by preparing Deformable vesicles which act as a nanocarrier to deliver the drug by changing their shape while transferring from the epidermis to hypodermis. The most advanced Nanocarriers are Ethosomes, Transferosomes, and transethosomes. In this article we will discuss about the transethosomes and their advancement in the TDDS, The transethosomes are prepared by the use of Phospholipids, Ethanol, Edge activators, and penetration enhancers used to make the deformable vesicles. They are prepared by Cold method, hot method, and thin film hydration methods. Their characterization studies include particle size, Shape, PDI, and entrapment efficiency, drug content, and in vitro evaluation studies. The applications of transethosomes are studied.