Abstract
ABSTRACTA total of 45 patients with acute hepatitis were detected in a medical facility of Bangladesh over a period of 6 months. All of them were physicians, nurses, students or employees of the hospital. About 50% of these patients suffered from acute hepatitis within a period of 2 months. All of them had clinical and biochemical evidences of acute hepatitis. All of them shared common working places as well as common dining and cooking facilities. Although the disease was supposed to be caused by hepatitis viruses, none of them were expressing IgM type antibody to hepatitis B core antigen (IgM anti-HBc) or hepatitis C virus (IgM anti-HCV). IgM type antibody to hepatitis A virus (IgM HAV) was detected in one patient and IgM type antibody to hepatitis E virus (anti-HEV IgM) were found in 14 patients. In conclusion, diagnosis of etiological agent of viral acute hepatitis constitutes a formidable challenge to the existing health care delivery system in developing countries as available serological and routine screening fails to find the proper etiological agent.How to cite this article: Mahtab MA, Akbar SMF, Podder DC, Saha PK, Jahan M, Begum L, Afrose T, Chowdhury F, Rahman S. An Outbreak of Acute Hepatitis in a Medical Facility of Bangladesh. Euroasian J Hepato-Gastroenterol 2014;4(1):66-67.
Highlights
Nonalcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome, a group of conditions including hypertension, high plasma glucose, excess body fat around waist or abnormal cholesterol levels, which will work together to increase the risk of heart disease, diabetes, and stroke.[1]
Significantly higher levels of resistin were detected in nonalcoholic fatty liver disease (NAFLD) patients compared to control subjects (p = 0.0001)
Higher levels of resistin were recorded in nonalcoholic steatohepatitis (NASH) group compared to the non-NASH group; the difference was not statistically significant (p = 0.584)
Summary
Nonalcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome, a group of conditions including hypertension, high plasma glucose, excess body fat around waist or abnormal cholesterol levels, which will work together to increase the risk of heart disease, diabetes, and stroke.[1]. The pathological spectrum of NAFLD ranges from simple hepatic steatosis to more severe manifestations, such as nonalcoholic steatohepatitis (NASH), hepatic fibrosis and cirrhosis.[2] Liver histology remains the gold standard for Euroasian Journal of Hepato-Gastroenterology, July-December 2014;4(2):[59-62] assessing disease severity in NAFLD. Biopsy is unsuitable for community studies and for studying hepatic fibrosis progression and histological assessment of NAFLD due to sampling error. This can lead to underestimation of the fibrosis score, especially when specimen is small.[3] Noninvasive panels of serological markers have been developed to evaluate the presence of steatosis and hepatic necroinflammation to avoid liver biopsy.[4]. In NAFLD patients, serum resistin was higher than those in control lean and obese patients
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