Abstract
The authors report an enantioselective organocatalytic approach to the total synthesis of lasubine II. Stereochemical information for both of the enantiomers of the natural product was set by using unmodified proline in a three-component Mannich reaction. Subsequent diastereoselective Mannich cyclization afforded the second chiral center, and a Grubbs metathesis followed by functional group manipulation completed the synthesis in a total of ten steps.
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