Abstract
Cell migration research has recently become both a high content and a high throughput field thanks to technological, computational, and methodological advances. Simultaneously, however, urgent bioinformatics needs regarding data management, standardization, and dissemination have emerged. To address these concerns, we propose to establish an open data ecosystem for cell migration research.
Highlights
Where is the cell migration field migrating to? Cell migration is crucial in biological processes such as morphogenesis, immune surveillance, wound healing, and cancer metastasis [1]
We propose to establish an open data ecosystem for cell migration research
The evolution of light microscopy from bright field to confocal, two photon, light sheet, and superresolution fluorescence microscopy has enabled the development of complex experimental systems, progressing from 2D cell migration assays to 2.5D and 3D approaches [2]
Summary
Cell migration is the product of complex processes operating at different scales, and could be investigated using a systems microscopy These advances in techniques and biological models have been supported by dedicated efforts in bioinformatics and computational biology (see Table S1 in the supplementary material online). Taking on the challenges: an open data ecosystem for cell migration Even though the cell migration field has embraced computational models as a means to integrate and interpret experiments, a key missing element is the global iterative connection between experimental data and computational approaches
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