Abstract
Cell Division One of the first recognized stages of an animal cell's entry into mitosis is the breakdown of the nuclear envelope (NE), a double-membraned structure that contains a cell's chromosomes. However, certain yeasts, including the lab workhorse Saccharomyces cerevisiae , keep their NE intact throughout mitosis; so-called closed mitosis. Makarova et al. studied two yeasts, one of which, Schizosaccharomyces japonicus , performs open mitosis, breaking down its NE during chromosome partitioning; and one of which, S. pombe , performs closed mitosis. They found that S. pombe –like mitotic regulation of a single lipid-modifying enzyme allowed S. japonicus to expand its NE and thus perform closed mitosis. Curr. Biol. 26 , 237 (2016)
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