Abstract
AbstarctCatheter associated thrombosis is an ongoing problem. Omniphobic coatings based on tethering biocompatible liquid lubricants on self-assembled monolayers of hydrophobic organosilanes attenuate clotting on surfaces. Herein we report an efficient, non-invasive and robust process for coating catheters with an antithrombotic, omniphobic lubricant-infused coating produced using chemical vapor deposition (CVD) of hydrophobic fluorine-based organosilanes. Compared with uncoated catheters, CVD coated catheters significantly attenuated thrombosis via the contact pathway of coagulation. When compared with the commonly used technique of liquid phase deposition (LPD) of fluorine-based organosilanes, the CVD method was more efficient and reproducible, resulted in less disruption of the outer polymeric layer of the catheters and produced greater antithrombotic activity. Therefore, omniphobic coating of catheters using the CVD method is a simple, straightforward and non-invasive procedure. This method has the potential to not only prevent catheter thrombosis, but also to prevent thrombosis on other blood-contacting medical devices.
Highlights
Blood-contacting medical devices such as catheters, heart valves and vascular grafts are widely used
Liquid phase deposition (LPD) is a well described method for producing self-assembled monolayers (SAMs) of fluorine-based silanes[38] and is the most widely used technique for producing omniphobic coatings on biomaterials[28,32], the results of this work show that the chemical vapor deposition (CVD) method is more efficient and effective than the LPD method for rendering medical grade polymeric catheters less thrombogenic
Such damage is evident from the X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) results
Summary
Blood-contacting medical devices such as catheters, heart valves and vascular grafts are widely used. Thrombosis on catheters and other blood-contacting medical devices is a multi-step process that starts with adhesion of proteins and cells, and culminates in the formation of a platelet-fibrin mesh[3,4]. Coagulation on these surfaces is activated via the contact pathway, which is initiated by the adsorption and activation of factor (F) XII5. To overcome the limitations of LPD, we set out to develop a more robust, simplified and clinically relevant chemical vapor deposition (CVD) method for creating a lubricant-infused omniphobic coating on FDA-approved catheters. We show that the CVD method has less of an effect on the surface topography of catheters than the LPD method and endows them with greater antithrombotic activity
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