An Observational Study of Propofol Mct-Lct Versus Propofol Lct with Lidocaine Pretreatment for Pain During Induction in General Anaesthesia

Abstract

Aims and Objectives: To compare efficacy between Propofol Medium Chain Triglycerides-Long ChainTriglycerides and Propofol Long Chain Triglycerides with lidocaine pretreatment under venous occlusionon propofol induced pain.Material and Methods: 50 patients of age 18 to 55 years of either gender of ASA I or II Grade were assignedto two groups of 25 each undergoing elective surgeries under general anaesthesia.Patients in Group Mreceived Propofol MCT-LCT 1% (without any pretreatment with Lidocaine) and Group L received PropofolLCT 1% with Lidocaine pretreatment under venous occlusion. Following propofol injection, patients wereasked for any sensation of pain at injection site during propofol injection till patient was unconscious. It wasgraded as per 4 point verbal pain score, with 0 being No pain to 3 being severe pain.Anaesthesia was induced by a standard technique of intravenous induction. Endotracheal intubation wasdone after giving injection succinyl choline (2mg/kg) I V and was maintained on O2, N2O, Isofluraneand Atracurium. Monitoring of heartrate, blood pressure and SPO2 were done during the surgery . Aftersurgery, reversal of neuromuscular blockade was done and extubation was performed. After that patient wastransferred to recovery room.Result and Summary: Both the groups were comparable in term of demographics and ASA grading. It wasobserved that in the group L a significantly higher proportion (80%) of patients experienced pain while inthe Group M only 44% patients experienced pain during propofol administration. (P value-0.0044- highlysignificant). We observed that the pain intensity score seen in group L was 0, 1, 2 and 3 in 20%, 48%, 20%and 12% of the patients , while in the group M was 0 and 1 in 56% and 44% of the patients, respectively andnone of the patients had pain score of 2 and 3. A significantly higher proportion of patients in group M hadpain intensity score of 0 (P value<0.01)which was statistically highly significant. Pre and post-operativevitals were comparable in both the groups.Conclusion: The study concluded that Propofol MCT-LCT is better in view of less incidence and severityof pain on injection during induction of anaesthesia than Propofol LCT with lidocaine pretreatment undervenous occlusion.