Comparative Evaluation of the Efficacy of Treatment with Intravenous Lignocaine and Intravenous Granisetron in Prevention of Pain Due to Intravenous Injection of Propofol

Abstract

Abstract Background Propofol is today considered the most common intravenous drug for the induction of general anesthesia. It is a drug with Phenol structure whose common complication is pain at the injection site as well as low blood pressure. Objective Comparison of treatment with granisetron versus lignocaine with respect to improvement of pain induced by injection of propofol, in patient admitted for elective surgery under general anesthesia. Materials and Methods This study was carried-out for Comparison of treatment with granisetron versus lignocaine with respect to improvement of pain induced by injection of propofol, in patient admitted for elective surgery under general anesthesia. This study was carried-out on 284 patients belonging to American Society of Anesthesiologists (ASA) physical status (PS) 1 and 2, of either sex, aged 18–60 years, scheduled for various elective surgical procedures under general anesthesia. The patients divided into 2 groups; Group 1 that consist of 142 patients which received injection of intravenous propofol (1-2 mg/kg) after injection with 1 ml of 2% lignocaine. Group 2 consist of another 142 which received injection of intravenous propofol (1-2 mg/kg) after injection with 1 ml of 1 ml of granisetron (1 mg/ml). Results The demographic data (age, body weight, sex ratio), physical status and type of surgery are not differ significantly (P > 0.05) among the two groups of this study. Our results on the heart rate, Systolic arterial blood pressure and diastolic arterial blood pressure showed no statistical significance after injection of lignocaine, granisetron and propofol at different points of time. The moderate and severe pain observed after different points of time from the injection of propofol can be reduced by injection of granisetron or lignocaine before propofol administration. Conclusion Our results concluded that, propofol commonly used as injection for induction of general anesthesia but it causes severe pain at the site of injection. For obtaining the best results and avoid the pain the patients must be received intravenous injection of granisetron or lignocaine. They can effectively reduce the severity of the pain resulted from propofol injection, granisetron is more effective for pain reduction than lignocaine.